Chemical SciencesWordPress

Henry Rzepa's Blog

Henry Rzepa's Blog
Chemistry with a twist
Home PageAtom Feed
language
Published

This is a continuation of the previous post exploring the transition state geometries of various types of ring closure as predicted by  Baldwin’s rules. I had dealt with bond formation to a trigonal (sp 2 ) carbon; now I add a digonal (sp) example (see an interesting literature variation).

Published

The Baldwin rules for ring closure follow the earlier ones by Bürgi and Dunitz in stating the preferred angles of nucleophilic (and electrophilic) attack in bond forming reactions, and are as famous for the interest in their exceptions as for their adherence. Both sets of rules fundamentally explore the geometry of the transition states involved in the reaction, as reflected in the activation free energies.