…but being straightforward is always the best approach. Since we published our paper in PLoS ONE a few months back I haven’t been as happy as I was about the activity of our Sortase. What this means is that we are now using a higher concentration of the enzyme to do our ligation reactions. They seem to be working well and with high yields, but we need to put in more enzyme.

Just a brief thought prompted by two, partly related, things streaming past my nose. Firstly Michael Nielsen discussed the views of Aristotle and Sunstein on collective intelligence. The thing that caught my attention was the idea that deliberation can make can make group functioning worse, leading to a collective decision that is muddled rather than actually identifying the best answer presented by members of the community.

For anyone in the UK who lives under a stone, or those people elsewhere in the world who don’t follow British news, this week there has been at least some news beyond the ongoing economic crisis and a U.S. election. Two media ‘personalities’ have been excoriated for leaving what can only be described as crass and offensive messages on an elderly actor’s answer phone, while on air.

The Research Information Network has put out a cal for expressions of interest in running a research project on how Web 2.0 tools are changing scientific practice. The project will be funded up to £90,000. Expressions of interest are due on Monday 3 November (yes next week) and the projects are due to start in January.

The Open Knowledge Foundation is running a workshop on finding and re-using open science resources. More details are available on the okf blog and wiki. I will be there along with a number of more interesting and important people. Come along and contribute to the discussion of how we can use what’s out there and how we can get a lot more of it.

This is the fourth and final part of the serialisation of a draft paper on Open Science. The other parts are here – Part I – Part II – Part III A question that needs to be asked when contemplating any major change in practice is the balance and timing of ‘bottom up’ versus ‘top-down’ approaches for achieving that change.

Greg Wilson and others are running a survey on how scientists’ perception of and use of software is changing.

The third installment of the paper (first part, second part) where I discuss social issues around practicing more Open Science. Scientists are inherently rather conservative in their adoption of new approaches and tools. A conservative approach has served the community well in the process of sifting ideas and claims;

I had been getting puzzled for a while as to why I was being characterised as an ‘Open Access’ advocate. I mean, I do adovcate Open Access publication and I have opinions on the Green versus Gold debate. I am trying to get more of my publications into Open Access journals. But I’m no expert, and I’ve certainly been around this community for a much shorter time and know a lot less about the detail than many other people.

Two rather exciting things are happening at the moment. Firstly we have finally got the LaBLog system up and running at RAL (http://biolab.isis.rl.ac.uk). Not a lot is happening there yet but we are gradually working up to a full Open Notebook status, starting by introducing people to the system bit by bit.